Scrapped Princess
Scrapped Princess starts off as a story of a fight between good and evil, but it soon turns into a story about friendship and brotherly love. The setting is pretty weird since it's obviously set in the middle ages (with all those swords and horses) but there are hints of advanced technology all over the place and there is talk about something called Genesis War... which was a war between humans and gods. The use of magic is substantial but the church doean't look kindly on it.
The Scrapped Princess also known as Pacifica Cassul has been prophecied as the poison who would destroy the world at the age of 16 and is thus being hunted by every single person on the planet (with few exceptions) and some creatures off the planet. After the death of her foster parents at the age of 15 she is being protected by her step-brother Shannon and step-sister Raquel. They are later joined by a knight-wannabe named Leopold.
All in all the 24 episode series is pretty enjoyable to watch. The character are nicely developed... personally I liked Raquel being so layed back, and Fulle's character was just amazing. There's also lots of comical situations that prevent the series getting too tense.